Polymer and plasticizer intermediates
Manufacturer descriptions identify azelaic acid as a monomer for polyesters and related plasticizer synthesis. [5]
01
THE ESSENTIALS
Azelaic Acid in 30 Seconds
Seven CH₂ groups separate its two carboxyl groups. There is no alkene or stereocenter in the neutral free-acid identity.
Azelaic acid is a nine-carbon saturated diacid with verified polymer-intermediate and formulated-drug contexts. Those contexts require different product qualifications. [1] [3]
Safety at a glance — Sigma 246379 classifies skin and eye irritation; TCI A1318 identifies serious eye irritation. Control dust and contact exposure for the supplied solid. The prescription-gel label reports formulation-specific irritation and other precautions; it is neither a raw-acid SDS nor a reason to minimize reagent hazards. [4] [5] [6]
A condensed structural formula keeps the functional groups visible. [1]
Qualified topical-drug context
The reviewed US label specifies azelaic acid at 15% w/w in a prescription gel for inflammatory papules and pustules of mild to moderate rosacea. [14]
Commercial availability
The supplier section separates package size, assay, grade, and market context for three named products. [4] [5] [6]
02
GO A LITTLE DEEPER
Understanding Azelaic Acid
THE SIMPLE EXPLANATION
The functional groups
Seven CH₂ groups separate its two carboxyl groups. There is no alkene or stereocenter in the neutral free-acid identity. [1]
A LITTLE DEEPER
What the structure changes
Condensation reactions incorporate azelate residues into polymers. In a pharmaceutical gel, azelaic acid is instead the active ingredient in a specified formulation. Neither identity relationship establishes that a general reagent is suitable for patient use. [1] [12]
Technical detail Identity, dissociation & specification
The neutral formula and molecular connectivity specify the free acid. A salt, ester, polymer, solution or carbonyl-hydration equilibrium requires its own description. Property references retain product, temperature, pressure and unresolved measurement qualifiers. [1] [2] [4] [5] [6]
Acid–base reference values describe equilibria under specified conditions. They are not a substitute for a validated formulation or an assay on the purchased lot.
03
MAKE THE CONNECTION
How Azelaic Acid Compares
Similar names and functional groups do not mean interchangeable chemicals.
SIDE-BY-SIDE COMPARISON
Azelaic Acid vs Sebacic Acid
Saturated aliphatic dicarboxylic acid
versusSaturated aliphatic dicarboxylic acid
Fixed comparison for this prototype. Acid selectors are disabled; additional comparisons are coming later.
| Property | Azelaic Acid | Sebacic Acid |
|---|---|---|
| Molecular formula | C₉H₁₆O₄ [1] | C₁₀H₁₈O₄ [7] |
| Molecular weight | 188.22 g/mol [1] | 202.25 g/mol [7] |
| Carbon atoms | 9 [1] | 10 [7] |
| Carboxyl groups | 2 [1] | 2 [7] |
| Structure | HOOC–(CH₂)₇–COOH [1] | HOOC–(CH₂)₈–COOH [7] |
| Chemical family | Saturated aliphatic dicarboxylic acid [1] | Saturated aliphatic dicarboxylic acid [7] |
| Identity focus | Free acid [1] | Free acid [7] |
Chemical identities are compared here; supplier grades, concentrations, and stereochemical specifications are separate purchasing attributes. pKa values retain their stated conditions; no quantitative solubility ranking is implied.
When Might You Choose One Instead of the Other?
Choose azelaic acid when the validated synthetic target or qualified formulation requires it. Choose sebacic acid for its ten-carbon residue. For pharmaceutical sourcing, establish the required compendial, impurity and quality-system documentation separately from chemical assay. [1] [3] [7]
Specified starting material
Azelaic Acid
Match HOOC–(CH₂)₇–COOH and the method’s required chemical form.
Sebacic Acid
Match HOOC–(CH₂)₈–COOH; verify the identity before substituting a related acid.
Before choosing: match the reaction or formulation, then verify the exact form, grade, assay basis, and impurities. These contexts do not establish suitability for an industrial or regulated application.
04
FROM STRUCTURE TO APPLICATION
What Is Azelaic Acid Used For?
Polymer and plasticizer intermediates
Manufacturer descriptions identify azelaic acid as a monomer for polyesters and related plasticizer synthesis. Polymer and plasticizer performance belongs to the derivative or finished material. [5]
Qualified topical-drug context
The reviewed US label specifies azelaic acid at 15% w/w in a prescription gel for inflammatory papules and pustules of mild to moderate rosacea. This direct formulated use does not qualify the displayed reagent powders for treatment. [14]
06
SOURCE WITH CONTEXT
Azelaic Acid Suppliers
Compare specific products and package options. Listings are not ranked recommendations.
3 suppliers · 3 products · 5 package listingsLatest supplier check: October 3, 2026
Package sizes stay grouped under the supplier product. Assay methods, product forms, and regional markets remain visible. TCI’s verified Austria-facing prices are EUR; Sigma and Wako listings are US dollar catalogs. Wako Practical Grade 95% titration is not equivalent to a 98% reagent or a pharmaceutical specification. No currency conversion or supplier-price ranking is supplied.
Scroll horizontally if needed. Supplier and package identity stay visible.
| Supplier | Product / Grade | Purity / Assay | Package Size | Public Price | Normalized Price | Documentation | Last Checked | Action |
|---|---|---|---|---|---|---|---|---|
| TCI EuropeAzelaic Acid | Named grade not statedA1318 · 25 gAustria-facing TCI Europe listing verified; US listing was not retrievable. No currency conversion or cross-market ranking. | GC: minimum 98.0% Neutralization titration: minimum 98.0% | 25 g | €23.00EUR · Austria / European public price | Not comparedDifferent currency / market | Document notes: TCI Europe
| View Product: TCI Europe, A1318 · 25 g (opens new tab) | |
| Named grade not statedA1318 · 250 gAustria-facing TCI Europe listing verified; US listing was not retrievable. No currency conversion or cross-market ranking. | GC: minimum 98.0% Neutralization titration: minimum 98.0% | 250 g | €142.00EUR · Austria / European public price | Not comparedDifferent currency / market | View Product: TCI Europe, A1318 · 250 g (opens new tab) | |||
| Sigma-AldrichAzelaic Acid | Named grade not stated246379-25G | 98%; assay method not stated | 25 g | $73.70USD · US public price | Not comparedGrades, assay bases, or forms differ | Document notes: Sigma-Aldrich
| View Product: Sigma-Aldrich, 246379-25G (opens new tab) | |
| Named grade not stated246379-100G | 98%; assay method not stated | 100 g | $190.00USD · US public price | Not comparedGrades, assay bases, or forms differ | View Product: Sigma-Aldrich, 246379-100G (opens new tab) | |||
| FUJIFILM WakoAzelaic Acid | Practical Grade012-08442Research / further manufacturing. Japan stock does not confirm US availability. A different assay threshold and grade from the 98% products; not an equivalent pharmaceutical raw material. | 95.0+% (Titration) | 25 g | $27.00USD · US catalog list price | Not comparedGrades, assay bases, or forms differ | Document notes: FUJIFILM Wako
| View Product: FUJIFILM Wako, 012-08442 (opens new tab) |
TCI Europe
Azelaic Acid
Neutralization titration: minimum 98.0%
Named grade not stated
Austria-facing TCI Europe listing verified; US listing was not retrievable. No currency conversion or cross-market ranking.
25 g
A1318 · 25 g- Public price
- €23.00EUR · Austria / European public price
- Normalized price
- Not comparedDifferent currency / market
250 g
A1318 · 250 g- Public price
- €142.00EUR · Austria / European public price
- Normalized price
- Not comparedDifferent currency / market
Documentation
Document notes: TCI Europe
- A product-specific certificate retrieval option was visible; no lot certificate was reviewed. Open the product page and use its certificate section.
- A current regional SDS was not verified in this pass.
- Origin-document availability was not verified. Country of origin is unverified and is not inferred.
Last checked:
Sigma-Aldrich
Azelaic Acid
Named grade not stated
25 g
246379-25G- Public price
- $73.70USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
100 g
246379-100G- Public price
- $190.00USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
Documentation
Document notes: Sigma-Aldrich
- A product-specific certificate retrieval option was visible; no lot certificate was reviewed. Open the product page and use its certificate section.
- A current regional SDS was not verified in this pass.
- Origin-document availability was not verified. Country of origin is unverified and is not inferred.
Last checked:
FUJIFILM Wako
Azelaic Acid
Practical Grade
Research / further manufacturing. Japan stock does not confirm US availability. A different assay threshold and grade from the 98% products; not an equivalent pharmaceutical raw material.
25 g
012-08442- Public price
- $27.00USD · US catalog list price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
Documentation
Document notes: FUJIFILM Wako
- A product-specific certificate retrieval option was visible; no lot certificate was reviewed. Open the product page and use its certificate section.
- A current regional SDS was not verified in this pass.
- Origin-document availability was not verified. Country of origin is unverified and is not inferred.
Last checked:
Documentation evidence
COA = Certificate of Analysis · SDS = Safety Data Sheet · COO = Certificate of Origin.
Lookup means a retrieval option was visible, not that a lot certificate was reviewed. Check supplier means availability or the applicable document was not verified.
Prices may vary by quantity, account, contract, geography, and availability. These products have different grades, assay bases, or forms; no normalized comparison is shown. Foreign-market prices are reference listings only. No currency conversion, mass-to-volume conversion, or ranking is applied. Confirm equivalent specifications and a current quote before comparison. [4] [5] [6]
Verification limits & placement policy
Melting point: CONFLICT UNRESOLVED. HSDB attributes 160.5 °C to CRC, whereas direct supplier references/specifications span about 100–111 °C. A transcription or identity cause was not established. The disputed literature number is not promoted as a constant; product specification is labeled separately. pKa: OMITTED. A compiled 4.55 does not establish the second dissociation or a matched temperature, ionic strength and method. No universal pair supplied. Boiling / decomposition: CONDITION-DEPENDENT. 286–287 °C references are at 100 mmHg. Atmospheric heating records around 360 °C include decomposition or anhydride formation and are not clean boiling constants. Higher-temperature solubility: CONFLICT UNRESOLVED. Compiled records give both 8.2 and 22 g/L at 50 °C without a resolved basis/method explanation. Those values are excluded.
Only the displayed identity, specification, packages, public prices and stated documentation evidence were reviewed. Current stock, lead times, shipping eligibility, contract pricing, lot certificates, and regulatory suitability are unverified.
There are no paid placements. Future paid listings will show “Sponsored” in both views; payment will not determine chemistry interpretation or imply a ranking.
07
PLAN A LARGER ORDER
Need Azelaic Acid in Bulk?
Turn your requirements into a clear supplier brief.
Bulk RFQ feature — coming soon. Prototype form: submissions are not currently sent to suppliers. Use sample details to prepare an on-screen brief.
Prepare a bulk request Prototype form
08
A BUYER’S CHECKLIST
Before You Buy Azelaic Acid
Selections remain only while this page is open.
09
FOR YOUR REFERENCE
Azelaic Acid Technical Reference
Identity, product reference properties, and handling context.
Identification Names, formula & identifiers
- Principal CAS
- 123-99-9
- Identity focus
- Free acid
- Formula
- C₉H₁₆O₄
- Molecular weight
- 188.22 g/mol
- IUPAC name
- nonanedioic acid
- Connectivity SMILES
- C(CCCC(=O)O)CCCC(=O)O
- Identity SMILES
- C(CCCC(=O)O)CCCC(=O)O
- InChI
- InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
- PubChem CID
- 2266
Connectivity SMILES describes connectivity; it is not an independent stereochemical assignment. CAS and product-form distinctions are supported by the supplier listings. [1] [4] [5] [6]
Physical Properties Product references & conditions
Solid at 20 °C. Literature melting entries conflict materially; the retained melting range is explicitly a TCI product specification. [13] [4] [5]
- Melting specification
- TCI A1318: 106–109 °C; specific product specification [4]
- Water-solubility reference
- 2.4 g/L at 20 °C; TCI reference agrees with attributed HSDB/Yalkowsky record; method not stated [4]
- Reduced-pressure boiling reference
- Sigma 246379: 286 °C at 100 mmHg; Wako lists 287 °C at 100 mmHg [5]
- Solid-density reference
- 1.225 g/cm³ at 25 °C; CRC (2014–2015), attributed in HSDB [13]
Hydrate, concentration, stereoisomer, and temperature can change the relevant specification. Product reference data are not a reviewed lot certificate.
Acid/Base Properties Verified values & missing data
A numeric pKa was not verified for the selected identity in this review; no value is inferred. [2]
Melting point: CONFLICT UNRESOLVED. HSDB attributes 160.5 °C to CRC, whereas direct supplier references/specifications span about 100–111 °C. A transcription or identity cause was not established. The disputed literature number is not promoted as a constant; product specification is labeled separately. pKa: OMITTED. A compiled 4.55 does not establish the second dissociation or a matched temperature, ionic strength and method. No universal pair supplied. Boiling / decomposition: CONDITION-DEPENDENT. 286–287 °C references are at 100 mmHg. Atmospheric heating records around 360 °C include decomposition or anhydride formation and are not clean boiling constants. Higher-temperature solubility: CONFLICT UNRESOLVED. Compiled records give both 8.2 and 22 g/L at 50 °C without a resolved basis/method explanation. Those values are excluded.
Temperature, ionic strength, and the use of activities versus concentrations matter in quantitative work. These reference values are not buffer recipes.
Safety at a Glance Product-specific hazards
Sigma 246379 classifies skin and eye irritation; TCI A1318 identifies serious eye irritation. Control dust and contact exposure for the supplied solid. The prescription-gel label reports formulation-specific irritation and other precautions; it is neither a raw-acid SDS nor a reason to minimize reagent hazards. [4] [5] [6]
Hazard classifications can vary by concentration, product, supplier and jurisdiction. Review the SDS for the exact product before handling. This summary does not replace the SDS.
Supplier safety information and SDS retrieval (opens new tab)
A product-page safety classification is not verification of every regional SDS. Confirm product code, chemical form and current local document.
Review supplier documentation10
COMMON QUESTIONS
Azelaic Acid FAQ
What distinguishes Azelaic Acid?
Seven CH₂ groups separate its two carboxyl groups. There is no alkene or stereocenter in the neutral free-acid identity. [1]
How does it differ from Sebacic Acid?
Sebacic acid contains one additional methylene. Both are saturated diacids, but their polymer residues and product specifications differ. A known azelaic-acid drug label does not establish a corresponding drug use for sebacic acid. [7]
What must a buyer specify?
TCI’s verified Austria-facing prices are EUR; Sigma and Wako listings are US dollar catalogs. Wako Practical Grade 95% titration is not equivalent to a 98% reagent or a pharmaceutical specification. No currency conversion or supplier-price ranking is supplied. [4]
Are the listed products directly price-comparable?
No. The table retains differing grades, assay bases, forms, and markets. No normalized ranking or currency conversion is applied. [5]
What reference data still need checking?
Melting point: CONFLICT UNRESOLVED. HSDB attributes 160.5 °C to CRC, whereas direct supplier references/specifications span about 100–111 °C. A transcription or identity cause was not established. The disputed literature number is not promoted as a constant; product specification is labeled separately. pKa: OMITTED. A compiled 4.55 does not establish the second dissociation or a matched temperature, ionic strength and method. No universal pair supplied. Boiling / decomposition: CONDITION-DEPENDENT. 286–287 °C references are at 100 mmHg. Atmospheric heating records around 360 °C include decomposition or anhydride formation and are not clean boiling constants. Higher-temperature solubility: CONFLICT UNRESOLVED. Compiled records give both 8.2 and 22 g/L at 50 °C without a resolved basis/method explanation. Those values are excluded.
Can I request a bulk quote here?
The RFQ is a prototype that prepares an on-screen brief. Nothing is sent to suppliers. Confirm actual bulk terms directly with the supplier.
11
TRACE THE INFORMATION
Sources & Editorial Notes
Identity and compiled reference values are separated from supplier-specific specifications. Structural comparisons and buyer guidance are editorial interpretation. Sources were checked October 3, 2026; supplier information can change.
- PubChem · chemical identity (opens new tab)
Neutral molecular identity verified independently through PUG REST; CAS also checked on all selected supplier products.
- PubChem / HSDB · dissociation references (opens new tab)
No numeric field promoted: insufficient conditions or unresolved conflicting records.
- PubChem / HSDB · application references (opens new tab)
Attributed application records reviewed claim by claim. Free acid, intermediate, derivative and biological context are distinguished.
- TCI Europe · commercial product (opens new tab)
Direct product checked October 3, 2026. Identity, listed assay methods, packages, market, prices and documentation interfaces inspected. Lot certificates and stock are not verified.
- Sigma-Aldrich · commercial product (opens new tab)
Direct product checked October 3, 2026. Identity, listed assay methods, packages, market, prices and documentation interfaces inspected. Lot certificates and stock are not verified.
- FUJIFILM Wako · commercial product (opens new tab)
Direct product checked October 3, 2026. Identity, listed assay methods, packages, market, prices and documentation interfaces inspected. Lot certificates and stock are not verified.
- Sebacic Acid · identity (opens new tab)
Primary structural comparison. Practical interpretation does not establish suitability.
- Suberic Acid · identity (opens new tab)
Related identity and structural relationship.
- Pimelic Acid · identity (opens new tab)
Related identity and structural relationship.
- Adipic Acid · identity (opens new tab)
Related identity and structural relationship.
- Sebacic Acid · dissociation references (opens new tab)
Only independently reviewed values are promoted into the comparison; no condition-free acidity ranking.
- OpenStax · Carboxylic-acid structure and properties (opens new tab)
General carboxylate resonance, acidity and structural interpretation; not authority for this acid’s quantitative constants.
- PubChem / HSDB · attributed physical references (opens new tab)
Only supported attributed references retained; source or method gaps and unresolved conflicts are stated.
- DailyMed · azelaic-acid 15% gel label (opens new tab)
December 2025 label: exact indication, 15% w/w formulation and product precautions verified.
Review limits
Melting point: CONFLICT UNRESOLVED. HSDB attributes 160.5 °C to CRC, whereas direct supplier references/specifications span about 100–111 °C. A transcription or identity cause was not established. The disputed literature number is not promoted as a constant; product specification is labeled separately. pKa: OMITTED. A compiled 4.55 does not establish the second dissociation or a matched temperature, ionic strength and method. No universal pair supplied. Boiling / decomposition: CONDITION-DEPENDENT. 286–287 °C references are at 100 mmHg. Atmospheric heating records around 360 °C include decomposition or anhydride formation and are not clean boiling constants. Higher-temperature solubility: CONFLICT UNRESOLVED. Compiled records give both 8.2 and 22 g/L at 50 °C without a resolved basis/method explanation. Those values are excluded.
This informational prototype is not a supplier, quotation service, or endorsement of a product’s fitness for an application. Buyers should verify the applicable specification, certification, and regulatory requirements for their intended use.