Analytical-standard context
Supelco 75462 is explicitly sold as a neat suberic-acid analytical standard with a GC assay. [14]
01
THE ESSENTIALS
Suberic Acid in 30 Seconds
Six methylene groups connect two terminal carboxyl groups. Octanedioic acid is the free acid; disuccinimidyl suberate is a chemically activated ester derivative.
Suberic acid is the eight-carbon saturated diacid. Analytical-standard products and activated suberate crosslinkers are separate commercial identities that must not be folded into a general reagent claim. [1] [3]
Safety at a glance — TCI O0023 identifies skin and eye irritation; Sigma S5200 identifies serious eye irritation. Dust and contact exposure require controls for the supplied solid. SDS classification must be obtained for the exact product; a derivative’s SDS is not substituted for free suberic acid. [4] [5] [6]
A condensed structural formula keeps the functional groups visible. [1]
Activated-derivative crosslinking context
Sigma S1885 identifies suberic acid bis(N-hydroxysuccinimide ester), also called DSS, as an amine-reactive crosslinker. [15]
Commercial availability
The supplier section separates package size, assay, grade, and market context for three named products. [4] [5] [6]
02
GO A LITTLE DEEPER
Understanding Suberic Acid
THE SIMPLE EXPLANATION
The functional groups
Six methylene groups connect two terminal carboxyl groups. Octanedioic acid is the free acid; disuccinimidyl suberate is a chemically activated ester derivative. [1]
A LITTLE DEEPER
What the structure changes
The free carboxyl groups can form salts and esters. An NHS-ester crosslinker has different reactive end groups and a different formula from suberic acid. Its amine-coupling activity is not an activity specification for the unactivated free acid. [1] [12]
Technical detail Identity, dissociation & specification
The neutral formula and molecular connectivity specify the free acid. A salt, ester, polymer, solution or carbonyl-hydration equilibrium requires its own description. Property references retain product, temperature, pressure and unresolved measurement qualifiers. [1] [2] [4] [5] [6]
Acid–base reference values describe equilibria under specified conditions. They are not a substitute for a validated formulation or an assay on the purchased lot.
03
MAKE THE CONNECTION
How Suberic Acid Compares
Similar names and functional groups do not mean interchangeable chemicals.
SIDE-BY-SIDE COMPARISON
Suberic Acid vs Pimelic Acid
Saturated aliphatic dicarboxylic acid
versusSaturated aliphatic dicarboxylic acid
Fixed comparison for this prototype. Acid selectors are disabled; additional comparisons are coming later.
| Property | Suberic Acid | Pimelic Acid |
|---|---|---|
| Molecular formula | C₈H₁₄O₄ [1] | C₇H₁₂O₄ [7] |
| Molecular weight | 174.19 g/mol [1] | 160.17 g/mol [7] |
| Carbon atoms | 8 [1] | 7 [7] |
| Carboxyl groups | 2 [1] | 2 [7] |
| Structure | HOOC–(CH₂)₆–COOH [1] | HOOC–(CH₂)₅–COOH [7] |
| Chemical family | Saturated aliphatic dicarboxylic acid [1] | Saturated aliphatic dicarboxylic acid [7] |
| Identity focus | Free acid [1] | Free acid [7] |
Chemical identities are compared here; supplier grades, concentrations, and stereochemical specifications are separate purchasing attributes. pKa values retain their stated conditions; no quantitative solubility ranking is implied.
When Might You Choose One Instead of the Other?
Choose suberic acid for an eight-carbon free-diacid target or a qualified analytical-standard requirement. Choose pimelic acid for the seven-carbon target. If a protocol specifies DSS, obtain that exact activated derivative rather than either free acid. [1] [3] [7]
Specified starting material
Suberic Acid
Match HOOC–(CH₂)₆–COOH and the method’s required chemical form.
Pimelic Acid
Match HOOC–(CH₂)₅–COOH; verify the identity before substituting a related acid.
Before choosing: match the reaction or formulation, then verify the exact form, grade, assay basis, and impurities. These contexts do not establish suitability for an industrial or regulated application.
04
FROM STRUCTURE TO APPLICATION
What Is Suberic Acid Used For?
Analytical-standard context
Supelco 75462 is explicitly sold as a neat suberic-acid analytical standard with a GC assay. This verifies a direct analytical context, but does not make the three general-reagent listings certified standards or food ingredients. [14]
Activated-derivative crosslinking context
Sigma S1885 identifies suberic acid bis(N-hydroxysuccinimide ester), also called DSS, as an amine-reactive crosslinker. This is a verified derivative use; free suberic acid is not the crosslinking reagent. [15]
06
SOURCE WITH CONTEXT
Suberic Acid Suppliers
Compare specific products and package options. Listings are not ranked recommendations.
3 suppliers · 3 products · 7 package listingsLatest supplier check: October 3, 2026
Package sizes stay grouped under the supplier product. Assay methods, product forms, and regional markets remain visible. TCI’s 99% GC and titration thresholds, Wako’s 98% titration and Sigma’s method-unspecified 98% are separate specifications. An analytical-standard grade from Supelco 75462 is not transferred to Sigma S5200 or another reagent.
Scroll horizontally if needed. Supplier and package identity stay visible.
| Supplier | Product / Grade | Purity / Assay | Package Size | Public Price | Normalized Price | Documentation | Last Checked | Action |
|---|---|---|---|---|---|---|---|---|
| TCI AmericaSuberic Acid | Named grade not statedO0023 · 25 g | GC: minimum 99.0% Neutralization titration: minimum 99.0% | 25 g | $28.00USD · US public price | Not comparedGrades, assay bases, or forms differ | Document notes: TCI America
| View Product: TCI America, O0023 · 25 g (opens new tab) | |
| Named grade not statedO0023 · 100 g | GC: minimum 99.0% Neutralization titration: minimum 99.0% | 100 g | $63.00USD · US public price | Not comparedGrades, assay bases, or forms differ | View Product: TCI America, O0023 · 100 g (opens new tab) | |||
| Named grade not statedO0023 · 500 g | GC: minimum 99.0% Neutralization titration: minimum 99.0% | 500 g | $189.00USD · US public price | Not comparedGrades, assay bases, or forms differ | View Product: TCI America, O0023 · 500 g (opens new tab) | |||
| Sigma-AldrichSuberic Acid | Named grade not statedS5200-5G | 98%; assay method not stated | 5 g | $73.30USD · US public price | Not comparedGrades, assay bases, or forms differ | Document notes: Sigma-Aldrich
| View Product: Sigma-Aldrich, S5200-5G (opens new tab) | |
| Named grade not statedS5200-100G | 98%; assay method not stated | 100 g | $116.00USD · US public price | Not comparedGrades, assay bases, or forms differ | View Product: Sigma-Aldrich, S5200-100G (opens new tab) | |||
| Named grade not statedS5200-500G | 98%; assay method not stated | 500 g | $173.00USD · US public price | Not comparedGrades, assay bases, or forms differ | View Product: Sigma-Aldrich, S5200-500G (opens new tab) | |||
| FUJIFILM WakoSuberic Acid | Wako Special Grade196-04312Research / further manufacturing. Japan stock does not confirm US availability. | 98.0+% (Titration) | 25 g | $78.00USD · US catalog list price | Not comparedGrades, assay bases, or forms differ | Document notes: FUJIFILM Wako
| View Product: FUJIFILM Wako, 196-04312 (opens new tab) |
TCI America
Suberic Acid
Neutralization titration: minimum 99.0%
Named grade not stated
25 g
O0023 · 25 g- Public price
- $28.00USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
100 g
O0023 · 100 g- Public price
- $63.00USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
500 g
O0023 · 500 g- Public price
- $189.00USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
Documentation
Document notes: TCI America
- A product-specific certificate retrieval option was visible; no lot certificate was reviewed. Open the product page and use its certificate section.
- A current regional SDS was not verified in this pass.
- Origin-document availability was not verified. Country of origin is unverified and is not inferred.
Last checked:
Sigma-Aldrich
Suberic Acid
Named grade not stated
5 g
S5200-5G- Public price
- $73.30USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
100 g
S5200-100G- Public price
- $116.00USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
500 g
S5200-500G- Public price
- $173.00USD · US public price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
Documentation
Document notes: Sigma-Aldrich
- A product-specific certificate retrieval option was visible; no lot certificate was reviewed. Open the product page and use its certificate section.
- A current regional SDS was not verified in this pass.
- Origin-document availability was not verified. Country of origin is unverified and is not inferred.
Last checked:
FUJIFILM Wako
Suberic Acid
Wako Special Grade
Research / further manufacturing. Japan stock does not confirm US availability.
25 g
196-04312- Public price
- $78.00USD · US catalog list price
- Normalized price
- Not comparedGrades, assay bases, or forms differ
Documentation
Document notes: FUJIFILM Wako
- A product-specific certificate retrieval option was visible; no lot certificate was reviewed. Open the product page and use its certificate section.
- A current regional SDS was not verified in this pass.
- Origin-document availability was not verified. Country of origin is unverified and is not inferred.
Last checked:
Documentation evidence
COA = Certificate of Analysis · SDS = Safety Data Sheet · COO = Certificate of Origin.
Lookup means a retrieval option was visible, not that a lot certificate was reviewed. Check supplier means availability or the applicable document was not verified.
Prices may vary by quantity, account, contract, geography, and availability. These products have different grades, assay bases, or forms; no normalized comparison is shown. Foreign-market prices are reference listings only. No currency conversion, mass-to-volume conversion, or ranking is applied. Confirm equivalent specifications and a current quote before comparison. [4] [5] [6]
Verification limits & placement policy
pKa / density: OMITTED. A sufficiently documented stepwise aqueous pKa pair and matched solid-density measurement were not verified. Boiling point: CONDITION-DEPENDENT. The retrieved 279 °C / 100 mmHg and 230 °C / 15 mmHg references differ in pressure. No pressure-free numeric comparison promoted. Water solubility: CONDITION-DEPENDENT. 1.6 g/L at 20 °C is a supplier reference with unstated method; do not treat it as a lot measurement.
Only the displayed identity, specification, packages, public prices and stated documentation evidence were reviewed. Current stock, lead times, shipping eligibility, contract pricing, lot certificates, and regulatory suitability are unverified.
There are no paid placements. Future paid listings will show “Sponsored” in both views; payment will not determine chemistry interpretation or imply a ranking.
07
PLAN A LARGER ORDER
Need Suberic Acid in Bulk?
Turn your requirements into a clear supplier brief.
Bulk RFQ feature — coming soon. Prototype form: submissions are not currently sent to suppliers. Use sample details to prepare an on-screen brief.
Prepare a bulk request Prototype form
08
A BUYER’S CHECKLIST
Before You Buy Suberic Acid
Selections remain only while this page is open.
09
FOR YOUR REFERENCE
Suberic Acid Technical Reference
Identity, product reference properties, and handling context.
Identification Names, formula & identifiers
- Principal CAS
- 505-48-6
- Identity focus
- Free acid
- Formula
- C₈H₁₄O₄
- Molecular weight
- 174.19 g/mol
- IUPAC name
- octanedioic acid
- Connectivity SMILES
- C(CCCC(=O)O)CCC(=O)O
- Identity SMILES
- C(CCCC(=O)O)CCC(=O)O
- InChI
- InChI=1S/C8H14O4/c9-7(10)5-3-1-2-4-6-8(11)12/h1-6H2,(H,9,10)(H,11,12)
- PubChem CID
- 10457
Connectivity SMILES describes connectivity; it is not an independent stereochemical assignment. CAS and product-form distinctions are supported by the supplier listings. [1] [4] [5] [6]
Physical Properties Product references & conditions
Solid at 20 °C. Reported boiling references are at reduced pressure and cannot be interpreted as ambient-pressure boiling temperatures. [13] [4] [5]
- Melting specification
- TCI O0023: 141–144 °C [4]
- Water-solubility reference
- TCI O0023: 1.6 g/L at 20 °C; measurement method not stated [4]
- Reduced-pressure boiling reference
- TCI O0023: 279 °C at 100 mmHg. Sigma S5200: 230 °C at 15 mmHg. [4]
Hydrate, concentration, stereoisomer, and temperature can change the relevant specification. Product reference data are not a reviewed lot certificate.
Acid/Base Properties Verified values & missing data
A numeric pKa was not verified for the selected identity in this review; no value is inferred. [2]
pKa / density: OMITTED. A sufficiently documented stepwise aqueous pKa pair and matched solid-density measurement were not verified. Boiling point: CONDITION-DEPENDENT. The retrieved 279 °C / 100 mmHg and 230 °C / 15 mmHg references differ in pressure. No pressure-free numeric comparison promoted. Water solubility: CONDITION-DEPENDENT. 1.6 g/L at 20 °C is a supplier reference with unstated method; do not treat it as a lot measurement.
Temperature, ionic strength, and the use of activities versus concentrations matter in quantitative work. These reference values are not buffer recipes.
Safety at a Glance Product-specific hazards
TCI O0023 identifies skin and eye irritation; Sigma S5200 identifies serious eye irritation. Dust and contact exposure require controls for the supplied solid. SDS classification must be obtained for the exact product; a derivative’s SDS is not substituted for free suberic acid. [4] [5] [6]
Hazard classifications can vary by concentration, product, supplier and jurisdiction. Review the SDS for the exact product before handling. This summary does not replace the SDS.
Supplier safety information and SDS retrieval (opens new tab)
A product-page safety classification is not verification of every regional SDS. Confirm product code, chemical form and current local document.
Review supplier documentation10
COMMON QUESTIONS
Suberic Acid FAQ
What distinguishes Suberic Acid?
Six methylene groups connect two terminal carboxyl groups. Octanedioic acid is the free acid; disuccinimidyl suberate is a chemically activated ester derivative. [1]
How does it differ from Pimelic Acid?
Suberic acid adds one methylene to pimelic acid. That changes the diacid residue incorporated by a synthesis. Neither acid can be substituted for an activated crosslinker merely because a product name includes suberate. [7]
What must a buyer specify?
TCI’s 99% GC and titration thresholds, Wako’s 98% titration and Sigma’s method-unspecified 98% are separate specifications. An analytical-standard grade from Supelco 75462 is not transferred to Sigma S5200 or another reagent. [4]
Are the listed products directly price-comparable?
No. The table retains differing grades, assay bases, forms, and markets. No normalized ranking or currency conversion is applied. [5]
What reference data still need checking?
pKa / density: OMITTED. A sufficiently documented stepwise aqueous pKa pair and matched solid-density measurement were not verified. Boiling point: CONDITION-DEPENDENT. The retrieved 279 °C / 100 mmHg and 230 °C / 15 mmHg references differ in pressure. No pressure-free numeric comparison promoted. Water solubility: CONDITION-DEPENDENT. 1.6 g/L at 20 °C is a supplier reference with unstated method; do not treat it as a lot measurement.
Can I request a bulk quote here?
The RFQ is a prototype that prepares an on-screen brief. Nothing is sent to suppliers. Confirm actual bulk terms directly with the supplier.
11
TRACE THE INFORMATION
Sources & Editorial Notes
Identity and compiled reference values are separated from supplier-specific specifications. Structural comparisons and buyer guidance are editorial interpretation. Sources were checked October 3, 2026; supplier information can change.
- PubChem · chemical identity (opens new tab)
Neutral molecular identity verified independently through PUG REST; CAS also checked on all selected supplier products.
- PubChem / HSDB · dissociation references (opens new tab)
No numeric field promoted: insufficient conditions or unresolved conflicting records.
- PubChem / HSDB · application references (opens new tab)
Attributed application records reviewed claim by claim. Free acid, intermediate, derivative and biological context are distinguished.
- TCI America · commercial product (opens new tab)
Direct product checked October 3, 2026. Identity, listed assay methods, packages, market, prices and documentation interfaces inspected. Lot certificates and stock are not verified.
- Sigma-Aldrich · commercial product (opens new tab)
Direct product checked October 3, 2026. Identity, listed assay methods, packages, market, prices and documentation interfaces inspected. Lot certificates and stock are not verified.
- FUJIFILM Wako · commercial product (opens new tab)
Direct product checked October 3, 2026. Identity, listed assay methods, packages, market, prices and documentation interfaces inspected. Lot certificates and stock are not verified.
- Pimelic Acid · identity (opens new tab)
Primary structural comparison. Practical interpretation does not establish suitability.
- Azelaic Acid · identity (opens new tab)
Related identity and structural relationship.
- Sebacic Acid · identity (opens new tab)
Related identity and structural relationship.
- Adipic Acid · identity (opens new tab)
Related identity and structural relationship.
- Pimelic Acid · dissociation references (opens new tab)
Only independently reviewed values are promoted into the comparison; no condition-free acidity ranking.
- OpenStax · Carboxylic-acid structure and properties (opens new tab)
General carboxylate resonance, acidity and structural interpretation; not authority for this acid’s quantitative constants.
- PubChem / HSDB · attributed physical references (opens new tab)
Only supported attributed references retained; source or method gaps and unresolved conflicts are stated.
- Supelco · suberic-acid analytical standard (opens new tab)
Neat analytical-standard grade and GC assay verified; not included in the general-reagent price table.
- Sigma · activated suberate derivative (opens new tab)
Distinct derivative CAS, formula and amine-reactive crosslinker role reviewed.
Review limits
pKa / density: OMITTED. A sufficiently documented stepwise aqueous pKa pair and matched solid-density measurement were not verified. Boiling point: CONDITION-DEPENDENT. The retrieved 279 °C / 100 mmHg and 230 °C / 15 mmHg references differ in pressure. No pressure-free numeric comparison promoted. Water solubility: CONDITION-DEPENDENT. 1.6 g/L at 20 °C is a supplier reference with unstated method; do not treat it as a lot measurement.
This informational prototype is not a supplier, quotation service, or endorsement of a product’s fitness for an application. Buyers should verify the applicable specification, certification, and regulatory requirements for their intended use.